Until a few months ago, Sally was our BSDB meeting secretary and she was outstanding in this role, bringing many new initiatives including the BSDB childcare and disability travel awards. She pushed hard in many ways for diversity, inclusivity and sustainability, so that during her tenure the BSDB became one of the leading drivers of new ways of running conferences.  This climaxed with our recent hosting of the European Dev Biol Congress where she pushed for – and made work – a programme made up largely of ECR speakers from across Europe, with a unique three hub arrangement with interdigitating talks beamed in from Paris and Barcelona to the central host hub of Oxford.  This was a pioneering “experiment” that could have gone badly wrong, but instead worked exceptionally well, and will have set a precedent for others to follow. Several colleagues from sister dev biol societies across Europe congratulated us on how brave the BSDB was to run such a meeting and how successful it had been.  This kudos for the BSDB was largely down to Sally.

Over the years, Sally has also held and still holds numerous other, largely unsung, roles in the dev biol and broader scientific community.  Some of those that are most relevant in the context of this Medal for communication and outreach include:

She is a Director of the CoB and chair of their sustainable conferencing initiative;

She is Co-Organiser (since 2014) of the Hydra summer school in stem cell and regenerative medicine;

She is part of the “prelights” scientific advisory group, which promotes open science and supporting of ECRs.

She is a trustee and the treasurer of the stem cell education and charitable initiative to support various science education projects;

She is the member for education on the Int Soc Stem Cell Research committee;

She is the outreach coordinator for the “Self organising built environment” with the Bartlett School of Planning, UCL, which explores links between dev biol and urban planning.

Sally instigated and has been involved in the set up and running of several sci-art exhibitions, linked to the BSDB Spring meeting. These have reached audiences outside of the developmental biology community.

All of these things that Sally has been doing for our community have helped popularise and widen participation in stem cell and developmental biology. In addition, she is also an outstanding scientist as reflected in her recent award in 2022 of the Int Soc Diffn, Anne McClaren Award for Outstanding Women in Dev Biol, and also being appointed a Fellow of the Academy of Medical Sciences (also in 2022). This makes her voice even more significant and she is a fabulous role model to all young scientists of how to be both collegiate and kind as well as an exceptional scientist.  We think she is someone who is worthy of the Wolpert medal through the numerous ways she enables and facilitates cross communication and success in others in our field, and we know she would be a fantastic ambassador for the BSDB when she gives her Wolpert medal tour lectures.

• Paul Martin
• Jens Januschke
• Cynthia Andoniadou

Originally trained as an engineer and physicist, JP Vincent became a developmental biologist by accident, when his PhD advisor George Oster, a mechanical engineer turned biologist, suggested that he look at the fluid dynamics of Xenopus eggs. He was lucky to be hosted by John Gerhart for the wet part of this project and was quickly taken by the warmth of the developmental biology community and the range of questions that developmental biology addresses. Since then, JP has been inspired by classical questions of developmental biology such as axis formation, cell fate determination, morphogen gradient formation and tissue renewal, and strived to bring methods from other disciplines to address them. His work has questioned established dogma, uncovered new mechanisms, and brought outsiders into the developmental biology field.

JP’s work has been a firework of exciting and fundamental discoveries that have helped shape developmental biology as we know it. JP’s PhD led him to uncover the subcortical rotation, which specifies the embryonic axis of frog embryos (1). Towards the end of his PhD, molecular biology began to permeate developmental biology and he felt that he had to be part of this revolution. He was thrown in the deep end by joining the lab of Pat O’Farrell and became fascinated by the process of cell fate specification. With this in mind, he developed, in collaboration with Tim Mitchison, the first photoactivable lineage tracer and used this to show that ‘posterior identity’, as recognised by the expression of engrailed, was stable but still open to change in response to signalling.

JP’s interest in the signaling pathways that control engrailed expression led to a love affair with Wnt signaling. In one early line of research, he showed that   Catenin exists in two exchangeable pools, one devoted to cell adhesion and the other to Wnt signaling, suggesting an intimate connection between signalling and morphogenesis (2). This paradigm-building discovery remains integral to our understanding of the Wnt signalling pathway. Influenced by discussions with Peter Lawrence, JP realized that it was important to determine the range of Wnt and other signaling proteins. Over the years, JP has identified many relevant factors and processes (e.g. endocytic trafficking, glypicans and feedback inhibitors) and has demonstrated their function in shaping Wingless morphogen gradients. In recent collaborative work with the group of Yvonne Jones, JP’s group showed how the carboxylesterase Notum inactivates Wnts in the extracellular space and how the glypican Dally-like accommodates the Wnt lipid (3-4). His discoveries, fuelled by extraordinary creativity and scientific playfulness, have provided a comprehensive model for how a paradigm morphogen gradient is created and maintained. His interest in the spread of signalling molecules has led him to another long-standing collaboration, with Guillaume Salbreux. Together, they showed that GFP could be repurposed as a morphogen, a key step towards synthetic developmental biology (5).

Throughout the course of his career, JP has created many new links between developmental biology and other disciplines, most prominently cell biology, physics, structural biology and chemistry. He has contributed to adapting various techniques to the needs of developmental biology. For example, he used HRP fusion proteins to track Wingless by EM. His senior scientific officer, Cyrille Alexandre, was the first to adapt CRISPR to Drosophila. He then devised sophisticated genome engineering approaches to express reporters and modified proteins from endogenous loci. Recently, with Yohanns Bellaiche, he developed optogenetic tools to control gene expression with unparalleled spatiotemporal precision. JP embodies the true spirit of collegiality in our community and generously shares reagents as soon as they are useable.

JP has contributed to a lively discourse within the developmental biology community. He has organised many conferences, including a BSDB spring meeting, two Developmental Biology Gordon conferences and two Jacques Monod conferences on Developmental mechanisms. JP was a member of the BSDB committee from 2000 to 2005 and of the BSCB committee from 2010 to 2015. He has served as an editor at Developmental Biology, Science Signalling and Phil Trans B. He is (or has been) on the scientific advisory board/review panel of various developmental biology departments (Curie’s Unit of Genetics and Developmental Biology, EMBL’s department of Developmental Biology, Institute de Biologie du Development de Marseille, Toulouse’s Centre for Integrative Biology, the Gurdon Institute, VIB’s department of Developmental Biology). He has lectured on morphogens and morphogenesis not only in academic settings but also at the University of the Third Age and to undergraduates at Cambridge and UCL. JP has mentored many young developmental biologists both within and outside his group, and many of his trainees have developed into independent developmental biologists.

• Alex Gould
• Ottoline Leyser
• Eugenia Piddini

Marysia Placzek is an outstanding and internationally leading Developmental Biologist who has made significant contributions to our understanding of how signalling directs patterning of the vertebrate nervous system, and to leadership and pedagogy of the field. Marysia uncovered how tissue interactions and combinations of signals regulate the organisation of cell fate and assembly of neural circuits in the spinal cord and hypothalamus. Her papers are masterworks in precise observation and elegant experimental design, and many have become foundational. As deputy and then acting Director of the MRC Centre for Developmental and Biomedical Genetics (2007-2013), Marysia has been instrumental in building Developmental Biology research at the University of Sheffield. She subsequently established the Bateson Centre, a cross-faculty inter-disciplinary research centre, to provide a focus for translational approaches to development and disease research at the University. In addition to leading research initiatives, Marysia is a passionate Developmental Biology teacher: running modules in Developmental Biology, Developmental Neurobiology, and Stem & Regenerative Biology. She is now bringing this, more than 20 years teaching experience, to a new role as co-editor, along with Cheryll Tickle, of Lewis Wolpert’s core textbook “Principles of Development”.

Following PhD research on proviral integration sites in mouse mammary carcinomas with Gordon Peters at the ICRF (1987-1992), Marysia moved to New York as a post-doc with Jane Dodd at Columbia University. During this time, she made two fundamental, textbook changing, contributions to our understanding of neural development. With Marc Tessier-Lavigne, she demonstrated that spinal cord floor-plate cells secrete a diffusible factor that influences the pattern and orientation of commissural axon growth (Nature 1988); this discovery presaged characterisation of the Netrin family of axon guidance molecules. She then went on to define the crucial role of the notochord/floor plate in patterning the central nervous system along its dorso-ventral axis (Science, 1990). The discovery of this fundamental tissue interaction underpinned the subsequent identification of Sonic hedgehog as the mediator of this activity, a breakthrough to which Marysia also contributed. As an independent investigator, Marysia has focussed on the role of the most anterior axial mesoderm, the prechordal plate, which emerges from the primitive streak just prior to the notochord. Marysia and her team have uncovered the mechanisms by which the prechordal plate orchestrates development of the hypothalamus (Cell 1997) and described the development of hypothalamic progenitors. A key discovery is the existence of a modified floor plate-like cell that displays stem cell-like characteristics and that gives rise to discrete hypothalamic progenitor cell populations, involving a mechanism that links cell specification and anisotropic growth (Developmental Cell 2006; Development 2017). By combining fate-mapping studies, classic embryological manipulations and cutting-edge molecular approaches, Marysia’s work is uncovering the developmental origins of these earliest hypothalamic stem/progenitor cells, and the signals that induce and constrain them (Development 2017; Cell Reports 2022). Together, her studies provide a roadmap for hypothalamic development, from its induction, to regionalisation, to neurogenesis, and challenge the widely accepted prosomere model of forebrain organization. Moreover, Marysia’s identification of this stem-like population in the embryo led to her work in the adult mouse, and one of the first detailed descriptions of the maintenance of neurogenic progenitors in the postnatal hypothalamus (Nature Comms. 2013), a paper that is widely cited as evidence for an adult hypothalamic stem cell niche.

Marysia is an embryologist par excellence and is known for her supportive mentoring of trainees. Her work is characterised by remarkable insight into tissue organisation of the early nervous system and an extraordinary ability to identify, dissect and manipulate unique cell populations. Her independent work has elucidated intrinsic and environmental mechanisms that regulate hypothalamic stem and progenitor cells across the life course. Marysia’s contributions to research have been recognised by award of the Otto Mangold Prize from the German Society for Developmental Biology (1999) and the MRC Suffrage Science Heirloom (2012). She has and continues to take a leading role in the Developmental Biology community and beyond. On return from USA as a new PI and new mother, she ran (with husband Andy Furley), an Autumn meeting for the BSDB (baby on hip), and faithfully sends her students and post-docs to BSDB meetings. Marysia has been a member of numerous funding panels for MRC, BBSRC, CRUK, and Wellcome Trust (see CV) and she is the current Chair of the new Wellcome Cell Biology, Development and Physiology Discovery Advisory Group. She is a very deserving candidate for the Waddington Medal.

• Kate Storey
• James Briscoe

Madeline is a most worthy recipient of the Tickle Medal. Madeline started her independent laboratory in 2015 at the Medical Research Council Laboratory of Molecular Biology (University of Cambridge) following landmark and courageous work developing organoids for the most complex and inaccessible of organs – the human brain. To do so, Madeline, looked to Developmental Biology to rationally decide upon conditions that might guide cellular self-organisation into variations of this organ, or regions or aspects of it (e.g., mimicking different axial levels and stages, more recently capable of secreting cerebrospinal fluid). Although there is not an embryo in sight, Madeline’s work has provided unprecedented functional access to models and perturbations relevant to understanding human brain development. It has also allowed probing of likely mechanisms of brain evolution and indeed its marriage with development, in the field of “evo-devo”. Finally, it has allowed investigation of intersections between development and human disease. Under her guidance, iterations of healthy and disease modelling brain organoids are contributing a wealth of what we could call equally “cellular synthetic biology” or “engineered developmental biology”. We are learning what it takes – at the molecular, cell biological, and supra-cellular levels – to coax cells into building particular fate and morphological ensembles that recapitulate important aspects of brain development.

In all, Madeline’s work speaks broadly not only to stem and developmental biologists, it illustrates the power of developmental biology to impact questions society at large cares deeply about such as what makes us (a healthy) human. Given the interest Madeline’s work has sparked, many developmental biologists are interested in adopting her models and her insight. Madeline is always happy to get people to visit to learn her protocols, welcoming interactions and collaborations. Finally, she has been very supportive of the first postdoc currently “flying the nest” towards an independent academic post.

• Rita Sousa-Nunes
• Jeremy Green